Exportin 1 inhibition as antiviral therapy
نویسندگان
چکیده
منابع مشابه
HIV-1 Capsid as a Target for Antiviral Therapy
Human immunodeficiency virus type 1 (HIV-1) is the causative virus responsible for acquired immune deficiency syndrome (AIDS), for which there is still no protective vaccine. Since 1983, more than 34 million people have been infected with HIV across the world, with 1.5 million people dying as a result of complications from infection each year. HIV-1 virions mainly infect cells of the immune sys...
متن کاملSpecific Inhibition of the Nuclear Exporter Exportin-1 Attenuates Kidney Cancer Growth
PURPOSE Despite the advent of FDA-approved therapeutics to a limited number of available targets (kinases and mTOR), PFS of kidney cancer (RCC) has been extended only one to two years due to the development of drug resistance. Here, we evaluate a novel therapeutic for RCC which targets the exportin-1 (XPO1) inhibitor. MATERIALS AND METHODS RCC cells were treated with the orally available XPO1...
متن کاملInhibition of exportin-1 function results in rapid cell cycle-associated DNA damage in cancer cells
Selective inhibitors of nuclear export (SINE) are small molecules in development as anti-cancer agents. The first-in-class SINE, selinexor, is in clinical trials for blood and solid cancers. Selinexor forms a covalent bond with exportin-1 at cysteine-528, and blocks its ability to export cargos. Previous work has shown strong cell cycle effects and drug-induced cell death across many different ...
متن کاملAntiviral Therapy
The current status of antiviral therapy is reviewed, including discussion of older approaches together with more recently developed chemotherapy. Following the introduction dealing with pathophysiological aspects of virus disease, the different approaches to antiviral therapy are presented. The reasons for the slow progress in antiviral therapy are discussed. These include: 1. the necessity of ...
متن کاملInduction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma
The nuclear transporter exportin-1 (XPO1) is highly expressed in mantle cell lymphoma (MCL) cells, and is believed to be associated with the pathogenesis of this disease. XPO1-selective inhibitors of nuclear export (SINE) compounds have been shown to induce apoptosis in MCL cells. Given that p53 is a cargo protein of XPO1, we sought to determine the significance of p53 activation through XPO1 i...
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ژورنال
عنوان ژورنال: Drug Discovery Today
سال: 2020
ISSN: 1359-6446
DOI: 10.1016/j.drudis.2020.06.014